Ontology highlight
ABSTRACT:
SUBMITTER: Poblete H
PROVIDER: S-EPMC4303662 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Poblete Horacio H Oyarzún Ingrid I Olivero Pablo P Comer Jeffrey J Zuñiga Matías M Sepulveda Romina V RV Báez-Nieto David D González Leon Carlos C González-Nilo Fernando F Latorre Ramón R
The Journal of biological chemistry 20141125 4
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) has been recognized as an important activator of certain transient receptor potential (TRP) channels. More specifically, TRPV1 is a pain receptor activated by a wide range of stimuli. However, whether or not PI(4,5)P2 is a TRPV1 agonist remains open to debate. Utilizing a combined approach of mutagenesis and molecular modeling, we identified a PI(4,5)P2 binding site located between the TRP box and the S4-S5 linker. At this site, PI(4,5)P2 interac ...[more]