Ontology highlight
ABSTRACT:
SUBMITTER: Furusawa T
PROVIDER: S-EPMC4304400 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Furusawa Takashi T Rochman Mark M Taher Leila L Dimitriadis Emilios K EK Nagashima Kunio K Anderson Stasia S Bustin Michael M
Nature communications 20150122
In most metazoan nuclei, heterochromatin is located at the nuclear periphery in contact with the nuclear lamina, which provides mechanical stability to the nucleus. We show that in cultured cells, chromatin decompaction by the nucleosome binding protein HMGN5 decreases the sturdiness, elasticity and rigidity of the nucleus. Mice overexpressing HMGN5, either globally or only in the heart, are normal at birth but develop hypertrophic heart with large cardiomyoctyes, deformed nuclei and disrupted l ...[more]