Ontology highlight
ABSTRACT:
SUBMITTER: Aloia L
PROVIDER: S-EPMC4304729 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Aloia Luigi L Gutierrez Arantxa A Caballero Juan Martin JM Di Croce Luciano L
EMBO reports 20141031 1
Id proteins are dominant-negative regulators within the HLH family of proteins. In embryonic stem cells (ESCs), Id1 and Id3 maintain the pluripotent state by preventing neural differentiation. The Id1-interacting protein Zrf1 plays a crucial role as a chromatin-bound factor in specification of the neural fate from ESCs. Here, we show that Id1 blocks Zrf1 recruitment to chromatin, thus preventing the activation of neural genes in ESCs. Upon differentiation, Id1 expression decreases thus inducing ...[more]