Ontology highlight
ABSTRACT:
SUBMITTER: Dempersmier J
PROVIDER: S-EPMC4304950 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Molecular cell 20150108 2
Uncoupling protein 1 (UCP1) mediates nonshivering thermogenesis and, upon cold exposure, is induced in brown adipose tissue (BAT) and subcutaneous white adipose tissue (iWAT). Here, by high-throughput screening using the UCP1 promoter, we identify Zfp516 as a transcriptional activator of UCP1 as well as PGC1α, thereby promoting a BAT program. Zfp516 itself is induced by cold and sympathetic stimulation through the cAMP-CREB/ATF2 pathway. Zfp516 directly binds to the proximal region of the UCP1 p ...[more]