Ontology highlight
ABSTRACT:
SUBMITTER: Ng R
PROVIDER: S-EPMC5637386 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Ng Raymond R Hussain Nurul Attiqah NA Zhang Qiongyi Q Chang Chengwei C Li Hongyu H Fu Yanyun Y Cao Lei L Han Weiping W Stunkel Walter W Xu Feng F
Cell reports 20170501 6
Brown adipose tissue (BAT) activation and subcutaneous white fat browning are essential components of the thermogenic response to cold stimulus in mammals. microRNAs have been shown to regulate both processes in cis. Here, we identify miR-32 as a BAT-specific super-enhancer-associated miRNA in mice that is selectively expressed in BAT and further upregulated during cold exposure. Inhibiting miR-32 in vivo led to impaired cold tolerance, decreased BAT thermogenesis, and compromised white fat brow ...[more]