Ontology highlight
ABSTRACT:
SUBMITTER: Sun X
PROVIDER: S-EPMC4304989 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Sun Xiaoshen X Hasanali Zainul S ZS Chen Allshine A Zhang Dianzheng D Liu Xin X Wang Hong-Gang HG Feith David J DJ Loughran Thomas P TP Xu Kailin K
British journal of haematology 20141004 3
Natural killer (NK) large granular lymphocyte (LGL) leukaemia features a clonal proliferation of CD3(-) NK cells that can be classified into either aggressive or chronic categories. The NKL cell line, derived from an aggressive Asian NK cell leukaemia, and patient samples from chronic NK-LGL leukaemia were used in our study to probe for synergistic efficacy of the epigenetic drugs vorinostat (SAHA) and cladribine in this disease. We demonstrate that histone deacetylases (HDACs) are over-expresse ...[more]