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Reduced mir-29b-3p expression up-regulate CDK6 and contributes to IgA nephropathy.

ABSTRACT: IgA nephropathy (IgAN) is the most common glomerulonephritis and the etiology of which is complex and multiple, and the pathological damage of IgAN is diversified. MicroRNA is a kind of gene expression suppressor and recently, researchers have found that microRNAs may play an important role in the pathogenesis of IgAN. Herein, we found that miR-29b-3p not miR-29a or miR-29c was significantly down regulated in IgAN patients' renal tissues. Predicted by bioinformatics tools and confirmed by dual luciferase assay and western blot, we found that the expression of CDK6 was repressed by miR-29b-3p directly. Subsequently, we found that miR-29b-3p down-regulation caused CDK6 overexpression can promote NF-?B signal by phosphorylating p65 which may enhance inflammation during IgAN pathogenesis.

SUBMITTER: Xing LN

PROVIDER: S-EPMC4307478 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Reduced mir-29b-3p expression up-regulate CDK6 and contributes to IgA nephropathy.

Xing Li-Na LN Wang Hao H Yin Pei-Hao PH Liu Yu-Jun YJ Chi Yang-Feng YF Wang Yun-Man YM Peng Wen W

International journal of clinical and experimental medicine 20141215 12

IgA nephropathy (IgAN) is the most common glomerulonephritis and the etiology of which is complex and multiple, and the pathological damage of IgAN is diversified. MicroRNA is a kind of gene expression suppressor and recently, researchers have found that microRNAs may play an important role in the pathogenesis of IgAN. Herein, we found that miR-29b-3p not miR-29a or miR-29c was significantly down regulated in IgAN patients' renal tissues. Predicted by bioinformatics tools and confirmed by dual l ...[more]

PMID: 25664031

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