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Subgroup variations in bone mineral density response to zoledronic acid after hip fracture.


ABSTRACT: Minimizing post-fracture bone loss is an important aspect of recovery from hip fracture, and determination of factors that affect bone mineral density (BMD) response to treatment after hip fracture may assist in the development of targeted therapeutic interventions. A post hoc analysis of the HORIZON Recurrent Fracture Trial was done to determine the effect of zoledronic acid (ZOL) on total hip (TH) and femoral neck (FN) BMD in subgroups with low-trauma hip fracture. A total of 2127 patients were randomized (1:1) to yearly infusions of ZOL 5?mg (n?=?1065) or placebo (n?=?1062) within 90 days of operation for low-trauma hip fracture. The 1486 patients with a baseline and at least one post-baseline BMD assessment at TH or FN (ZOL?=?745, placebo?=?741) were included in the analyses. Percentage change from baseline in TH and FN BMD was assessed at months 12 and 24 and compared across subgroups of hip fracture patients. Percentage change from baseline in TH and FN BMD at months 12 and 24 was greater (p?6 weeks post-surgery; and for TH and FN BMD in patients with a history of one or more prior fractures. All interactions were limited to the first 12 months after treatment with none observed for the 24-month comparisons. (Clinical trial registration number NCT00046254.)

SUBMITTER: Magaziner JS 

PROVIDER: S-EPMC4307640 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

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Subgroup variations in bone mineral density response to zoledronic acid after hip fracture.

Magaziner Jay S JS   Orwig Denise L DL   Lyles Kenneth W KW   Nordsletten Lars L   Boonen Steven S   Adachi Jonathan D JD   Recknor Chris C   Colón-Emeric Cathleen S CS   Mesenbrink Peter P   Bucci-Rechtweg Christina C   Su Guoqin G   Johnson Rasheeda R   Pieper Carl F CF  

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20141201 12


Minimizing post-fracture bone loss is an important aspect of recovery from hip fracture, and determination of factors that affect bone mineral density (BMD) response to treatment after hip fracture may assist in the development of targeted therapeutic interventions. A post hoc analysis of the HORIZON Recurrent Fracture Trial was done to determine the effect of zoledronic acid (ZOL) on total hip (TH) and femoral neck (FN) BMD in subgroups with low-trauma hip fracture. A total of 2127 patients wer  ...[more]

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