Ontology highlight
ABSTRACT:
SUBMITTER: Chimerel C
PROVIDER: S-EPMC4308618 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Chimerel Catalin C Emery Edward E Summers David K DK Keyser Ulrich U Gribble Fiona M FM Reimann Frank F
Cell reports 20141113 4
It has long been speculated that metabolites, produced by gut microbiota, influence host metabolism in health and diseases. Here, we reveal that indole, a metabolite produced from the dissimilation of tryptophan, is able to modulate the secretion of glucagon-like peptide-1 (GLP-1) from immortalized and primary mouse colonic L cells. Indole increased GLP-1 release during short exposures, but it reduced secretion over longer periods. These effects were attributed to the ability of indole to affect ...[more]