Ontology highlight
ABSTRACT:
SUBMITTER: Chandler RL
PROVIDER: S-EPMC4308813 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Chandler Ronald L RL Damrauer Jeffrey S JS Raab Jesse R JR Schisler Jonathan C JC Wilkerson Matthew D MD Didion John P JP Starmer Joshua J Serber Daniel D Yee Della D Xiong Jessie J Darr David B DB Pardo-Manuel de Villena Fernando F Kim William Y WY Magnuson Terry T
Nature communications 20150127
Ovarian clear-cell carcinoma (OCCC) is an aggressive form of ovarian cancer with high ARID1A mutation rates. Here we present a mutant mouse model of OCCC. We find that ARID1A inactivation is not sufficient for tumour formation, but requires concurrent activation of the phosphoinositide 3-kinase catalytic subunit, PIK3CA. Remarkably, the mice develop highly penetrant tumours with OCCC-like histopathology, culminating in haemorrhagic ascites and a median survival period of 7.5 weeks. Therapeutic t ...[more]