Ontology highlight
ABSTRACT:
SUBMITTER: Kim M
PROVIDER: S-EPMC7734570 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Kim Minchul M Lu Falong F Zhang Yi Y
Cell reports 20160901 1
ARID1A is frequently mutated in ovarian clear cell carcinoma (OCCC) and often co-exists with activating mutations of PIK3CA. Although induction of pro-inflammatory cytokines has been observed in this cancer, the mechanism by which the two mutations synergistically activate cytokine genes remains elusive. Here, we established an in vitro model of OCCC by introducing ARID1A knockdown and mutant PIK3CA into a normal human ovarian epithelial cell line, resulting in cell transformation and cytokine g ...[more]