Inhibition of Theiler's virus-induced apoptosis in infected murine macrophages results in necroptosis.
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ABSTRACT:
SUBMITTER: Son KN
PROVIDER: S-EPMC4309367 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
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Inhibition of Theiler's virus-induced apoptosis in infected murine macrophages results in necroptosis.
Son Kyung-No KN Lipton Howard L HL
Virus research 20141027
In mice Theiler's murine encephalomyelitis virus (TMEV) persists in macrophages that eventually undergo apoptosis. TMEV infection of macrophages in culture induces apoptosis through the intrinsic pathway, restricting virus yields. We show that inhibition of TMEV-induced apoptosis leads to phosphorylation of receptor interacting protein 1 (RIP1), localization of RIP1 and RIP3 to mitochondria, ROS production independent of MAPK activation and programmed necrosis (necroptosis). Blocking both apopto ...[more]
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