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Meta-analysis of anti-muscarinic receptor type 3 antibodies for the diagnosis of Sjogren syndrome.

ABSTRACT:

Purpose

To conduct a meta-analysis to evaluate the diagnostic value of anti-muscarinic receptor type 3 (M3R) antibodies in Sjögren syndrome (SS).

Methods

Two databases, PUBMED and the Cochrane Library, were systematically searched. Approximately 2,000 participants from several studies were included in this research. STATA 11.2 software and Meta-DiSc 1.4 was used to conduct the meta-analysis.

Results

Eleven studies were included in the meta-analysis. The pooled DOR was 13.00 (95% CI, 6.00-26.00). The sensitivity was 0.43 (95% CI, 0.28-0.58) and the specificity was 0.95 (95%CI, 0.91-0.97). The LR+ and LR- were 7.90 (95% CI, 4.70-13.40), 0.61 (95% CI, 0.46-0.79), respectively. The AUC was 0.89 (95% CI, 0.86-0.92).

Conclusion

The anti-M3R antibody had high specificity but relatively low sensitivity for the diagnosis of SS.

SUBMITTER: Deng C

PROVIDER: S-EPMC4309563 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Meta-analysis of anti-muscarinic receptor type 3 antibodies for the diagnosis of Sjögren syndrome.

Deng Chuiwen C Hu Chaojun C Chen Si S Li Jing J Wen Xiaoting X Wu Ziyan Z Li Yuan Y Zhang Fengchun F Li Yongzhe Y

PloS one 20150128 1

<h4>Purpose</h4>To conduct a meta-analysis to evaluate the diagnostic value of anti-muscarinic receptor type 3 (M3R) antibodies in Sjögren syndrome (SS).<h4>Methods</h4>Two databases, PUBMED and the Cochrane Library, were systematically searched. Approximately 2,000 participants from several studies were included in this research. STATA 11.2 software and Meta-DiSc 1.4 was used to conduct the meta-analysis.<h4>Results</h4>Eleven studies were included in the meta-analysis. The pooled DOR was 13.00 ...[more]

PMID: 25629973

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