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Current Therapeutic Advances Targeting EGFR and EGFRvIII in Glioblastoma.

ABSTRACT: Epidermal growth factor receptor (EGFR) and EGFRvIII analysis is of current interest in glioblastoma - the most common malignant primary CNS tumor, because of new EGFRvIII vaccine trials underway. EGFR activation in glioblastoma promotes cellular proliferation via activation of MAPK and PI3K-Akt pathways, and EGFRvIII is the most common variant, leading to constitutively active EGFR. This review explains EGFR and EGFRvIII signaling in GBM; describes targeted therapy approaches to date including tyrosine kinase inhibitor, antibody-based therapies, vaccines and pre-clinical RNA-based therapies, and discusses the difficulties encountered with these approaches including pathway redundancy and intratumoral heterogeneity.

SUBMITTER: Padfield E

PROVIDER: S-EPMC4310282 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Current Therapeutic Advances Targeting EGFR and EGFRvIII in Glioblastoma.

Padfield Emily E Ellis Hayley P HP Kurian Kathreena M KM

Frontiers in oncology 20150129

Epidermal growth factor receptor (EGFR) and EGFRvIII analysis is of current interest in glioblastoma - the most common malignant primary CNS tumor, because of new EGFRvIII vaccine trials underway. EGFR activation in glioblastoma promotes cellular proliferation via activation of MAPK and PI3K-Akt pathways, and EGFRvIII is the most common variant, leading to constitutively active EGFR. This review explains EGFR and EGFRvIII signaling in GBM; describes targeted therapy approaches to date including ...[more]

PMID: 25688333

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