Ontology highlight
ABSTRACT:
SUBMITTER: Velpula KK
PROVIDER: S-EPMC5482605 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Velpula Kiran K KK Guda Maheedhara R MR Sahu Kamlesh K Tuszynski Jack J Asuthkar Swapna S Bach Sarah E SE Lathia Justin D JD Tsung Andrew J AJ
Oncotarget 20170501 22
Glioblastomas are characterized by amplification of EGFR. Approximately half of tumors with EGFR over-expression also express a constitutively active ligand independent EGFR variant III (EGFRvIII). While current treatments emphasize surgery followed by radiation and chemotherapy with Temozolomide (TMZ), acquired chemoresistance is a universal feature of recurrent GBMs. To mimic the GBM resistant state, we generated an in vitro TMZ resistant model and demonstrated that dichloroacetate (DCA), a me ...[more]