Triggering of RNA interference with RNA-RNA, RNA-DNA, and DNA-RNA nanoparticles.
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ABSTRACT:
SUBMITTER: Afonin KA
PROVIDER: S-EPMC4310632 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Publications
Triggering of RNA interference with RNA-RNA, RNA-DNA, and DNA-RNA nanoparticles.
Afonin Kirill A KA Viard Mathias M Kagiampakis Ioannis I Case Christopher L CL Dobrovolskaia Marina A MA Hofmann Jen J Vrzak Ashlee A Kireeva Maria M Kasprzak Wojciech K WK KewalRamani Vineet N VN Shapiro Bruce A BA
ACS nano 20141218 1
Control over cellular delivery of different functionalities and their synchronized activation is a challenging task. We report several RNA and RNA/DNA-based nanoparticles designed to conditionally activate the RNA interference in various human cells. These nanoparticles allow precise control over their formulation, stability in blood serum, and activation of multiple functionalities. Importantly, interferon and pro-inflammatory cytokine activation assays indicate the significantly lower response ...[more]
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