Distinct kinetics of viral replication, T cell infiltration, and fibrosis in three phases of myocarditis following Theiler's virus infection.
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ABSTRACT:
SUBMITTER: Sato F
PROVIDER: S-EPMC4310790 | biostudies-literature | 2014 Nov-Dec
REPOSITORIES: biostudies-literature
Publications
Distinct kinetics of viral replication, T cell infiltration, and fibrosis in three phases of myocarditis following Theiler's virus infection.
Sato Fumitaka F Omura Seiichi S Kawai Eiichiro E Martinez Nicholas E NE Acharya Madan M MM Reddy Pratap C PC Chaitanya Ganta V GV Alexander J Steven JS Tsunoda Ikuo I
Cellular immunology 20141101 1-2
We established a novel model of myocarditis induced with Theiler’s murine encephalomyelitis virus (TMEV), which has been used as a viral model for multiple sclerosis and seizure/epilepsy. Following TMEV infection, C3H mice developed severe myocarditis with T cell infiltration, while C57BL/6 mice had mild lesions and SJL/J mice had no inflammation in the heart. In C3H mice, myocarditis was divided into three phases: acute viral, subacute immune, and chronic fibrotic phases. Using toll-like recept ...[more]
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