Ontology highlight
ABSTRACT:
SUBMITTER: Arnold DL
PROVIDER: S-EPMC4311432 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Arnold Douglas L DL Calabresi Peter A PA Kieseier Bernd C BC Sheikh Sarah I SI Deykin Aaron A Zhu Ying Y Liu Shifang S You Xiaojun X Sperling Bjoern B Hung Serena S
BMC neurology 20141231
<h4>Background</h4>Subcutaneous peginterferon beta-1a provided clinical benefits at Year 1 (placebo-controlled period) of the 2-Year Phase 3 ADVANCE study in relapsing-remitting multiple sclerosis (RRMS). Here we report the effect of peginterferon beta-1a on brain magnetic resonance imaging (MRI) lesions, and no evidence of disease activity (NEDA; absence of clinical [relapses and 12-week confirmed disability progression] and MRI [gadolinium-enhancing, and new or newly-enlarging T2 hyperintense ...[more]