Loss of wwox expression in zebrafish embryos causes edema and alters Ca(2+) dynamics.
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ABSTRACT:
SUBMITTER: Tsuruwaka Y
PROVIDER: S-EPMC4312067 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Loss of wwox expression in zebrafish embryos causes edema and alters Ca(2+) dynamics.
Tsuruwaka Yusuke Y Konishi Masataka M Shimada Eriko E
PeerJ 20150127
We investigated the role of the WW domain-containing oxidoreductase (wwox) gene in the embryonic development of zebrafish, with particular emphasis on intracellular Ca(2+) dynamics because Ca(2+) is an important intracellular messenger. Comparisons between zebrafish wwox and human WWOX sequences identified highly conserved domain structures. wwox was expressed in developing heart tissues in the zebrafish embryo. Moreover, wwox knockdown induced pericardial edema with similarities to conditions o ...[more]
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