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Synthesis and antiviral evaluation of 2-amino-6-carbamoylpurine dioxolane nucleoside derivatives and their phosphoramidates prodrugs.

ABSTRACT: The synthesis of 9-(?-d-1,3-dioxolan-4-yl)2,6-diaminopurine nucleoside phosphoramidate prodrugs as well as various 2-amino-6-carbamoylpurine dioxolane derivatives and their phosphoramidates prodrugs is reported. Their ability to block HIV and HBV replication along with their cytotoxicity toward HepG2, human lymphocyte, CEM and Vero cells was also assessed.

SUBMITTER: Cho JH

PROVIDER: S-EPMC4312240 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

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Synthesis and antiviral evaluation of 2-amino-6-carbamoylpurine dioxolane nucleoside derivatives and their phosphoramidates prodrugs.

Cho Jong Hyun JH Bondana Lavanya L Detorio Mervi A MA Montero Cathy C Bassit Leda C LC Amblard Franck F Coats Steven J SJ Schinazi Raymond F RF

Bioorganic & medicinal chemistry 20141013 23

The synthesis of 9-(β-d-1,3-dioxolan-4-yl)2,6-diaminopurine nucleoside phosphoramidate prodrugs as well as various 2-amino-6-carbamoylpurine dioxolane derivatives and their phosphoramidates prodrugs is reported. Their ability to block HIV and HBV replication along with their cytotoxicity toward HepG2, human lymphocyte, CEM and Vero cells was also assessed. ...[more]

PMID: 25458500

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