Ontology highlight
ABSTRACT:
SUBMITTER: Villar D
PROVIDER: S-EPMC4313353 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Villar Diego D Berthelot Camille C Aldridge Sarah S Rayner Tim F TF Lukk Margus M Pignatelli Miguel M Park Thomas J TJ Deaville Robert R Erichsen Jonathan T JT Jasinska Anna J AJ Turner James M A JM Bertelsen Mads F MF Murchison Elizabeth P EP Flicek Paul P Odom Duncan T DT
Cell 20150101 3
The mammalian radiation has corresponded with rapid changes in noncoding regions of the genome, but we lack a comprehensive understanding of regulatory evolution in mammals. Here, we track the evolution of promoters and enhancers active in liver across 20 mammalian species from six diverse orders by profiling genomic enrichment of H3K27 acetylation and H3K4 trimethylation. We report that rapid evolution of enhancers is a universal feature of mammalian genomes. Most of the recently evolved enhanc ...[more]