Ontology highlight
ABSTRACT:
SUBMITTER: Spencer SP
PROVIDER: S-EPMC4313730 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20140101 6169
How the immune system adapts to malnutrition to sustain immunity at barrier surfaces, such as the intestine, remains unclear. Vitamin A deficiency is one of the most common micronutrient deficiencies and is associated with profound defects in adaptive immunity. Here, we found that type 3 innate lymphoid cells (ILC3s) are severely diminished in vitamin A-deficient settings, which results in compromised immunity to acute bacterial infection. However, vitamin A deprivation paradoxically resulted in ...[more]