Ontology highlight
ABSTRACT:
SUBMITTER: Galle-Treger L
PROVIDER: S-EPMC6372786 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Galle-Treger Lauriane L Sankaranarayanan Ishwarya I Hurrell Benjamin P BP Howard Emily E Lo Richard R Maazi Hadi H Lewis Gavin G Banie Homayon H Epstein Alan L AL Hu Peisheng P Rehan Virender K VK Gilliland Frank D FD Allayee Hooman H Soroosh Pejman P Sharpe Arlene H AH Akbari Omid O
Nature communications 20190212 1
Metabolic syndrome is characterized by disturbances in glucose homeostasis and the development of low-grade systemic inflammation, which increase the risk to develop type 2 diabetes mellitus (T2DM). Type-2 innate lymphoid cells (ILC2s) are a recently discovered immune population secreting Th2 cytokines. While previous studies show how ILC2s can play a critical role in the regulation of metabolic homeostasis in the adipose tissue, a therapeutic target capable of modulating ILC2 activation has yet ...[more]