Ontology highlight
ABSTRACT:
SUBMITTER: Yu M
PROVIDER: S-EPMC4314628 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Yu Miao M Wang Jinghe J Muller Daniel J DJ Helenius Jonne J
Scientific reports 20150203
Eph receptor (Eph) and ephrin signaling can play central roles in prostate cancer and other cancer types. Exposed to ephrin-A1 PC3 prostate cancer cells alter adhesion to extracellular matrix (ECM) proteins. However, whether PC3 cells increase or reduce adhesion, and by which mechanisms they change adhesion to the ECM remains to be characterized. Here, we assay how ephrin-A1 stimulates PC3 cells to adhere to ECM proteins using single-cell force spectroscopy. We find that PC3 cells binding to imm ...[more]