Genome-wide crosstalk between steroid receptors in breast and prostate cancers.

ABSTRACT: Steroid receptors (SRs) constitute an important class of signal-dependent transcription factors (TFs). They regulate a variety of key biological processes and are crucial drug targets in many disease states. In particular, estrogen (ER) and androgen receptors (AR) drive the development and progression of breast and prostate cancer, respectively. Thus, they represent the main specific drug targets in these diseases. Recent evidence has suggested that the crosstalk between signal-dependent TFs is an important step in the reprogramming of chromatin sites; a signal-activated TF can expand or restrict the chromatin binding of another TF. This crosstalk can rewire gene programs and thus alter biological processes and influence the progression of disease. Lately, it has been postulated that there

SUBMITTER: Paakinaho V 

PROVIDER: S-EPMC8345902 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature