Ontology highlight
ABSTRACT:
SUBMITTER: Kant R
PROVIDER: S-EPMC4314633 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Kant Ravi R Pasi Shweta S Surolia Avadhesha A
Scientific reports 20150203
MBP(85-99), an immuno-dominant epitope of myelin basic protein which binds to the major histocompatibility complex haplotype HLA-DR2 is widely implicated in the pathogenesis of multiple sclerosis. J5, an antagonist of MBP(85-99), that blocks the binding of MBP(85-99) to soluble HLA-DR2b much more efficiently than glatiramer acetate (a random copolymer comprising major MHC and T-cell receptor contact residues), was transformed into analogs with superior biological half-lives and antagonistic-acti ...[more]