HIF-1? restricts NF-?B-dependent gene expression to control innate immunity signals.
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ABSTRACT:
SUBMITTER: Bandarra D
PROVIDER: S-EPMC4314782 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Publications
HIF-1α restricts NF-κB-dependent gene expression to control innate immunity signals.
Bandarra Daniel D Biddlestone John J Mudie Sharon S Müller H-Arno J HA Rocha Sonia S
Disease models & mechanisms 20141215 2
Hypoxia and inflammation are intimately linked. It is known that nuclear factor κB (NF-κB) regulates the hypoxia-inducible factor (HIF) system, but little is known about how HIF regulates NF-κB. Here, we show that HIF-1α represses NF-κB-dependent gene expression. HIF-1α depletion results in increased NF-κB transcriptional activity both in mammalian cells and in the model organism Drosophila melanogaster. HIF-1α depletion enhances the NF-κB response, and this required not only the TAK-IKK complex ...[more]
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