Ontology highlight
ABSTRACT:
SUBMITTER: D'Ignazio L
PROVIDER: S-EPMC7216149 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
D'Ignazio Laura L Shakir Dilem D Batie Michael M Muller H Arno HA Rocha Sonia S
International journal of molecular sciences 20200424 8
NF-κB signalling is crucial for cellular responses to inflammation but is also associated with the hypoxia response. NF-κB and hypoxia inducible factor (HIF) transcription factors possess an intense molecular crosstalk. Although it is known that HIF-1α modulates NF-κB transcriptional response, very little is understood regarding how HIF-1β contributes to NF-κB signalling. Here, we demonstrate that HIF-1β is required for full NF-κB activation in cells following canonical and non-canonical stimuli ...[more]