Ontology highlight
ABSTRACT:
SUBMITTER: Almeida L
PROVIDER: S-EPMC4315723 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 20150103
Previous studies have demonstrated a role for wound healing genes in resolution of cutaneous lesions caused by Leishmania spp. in both mice and humans, including the gene FLI1 encoding Friend leukemia virus integration 1. Reduction of Fli1 expression in mice has been shown to result in up-regulation of collagen type I alpha 1 (Col1a1) and alpha 2 (Col1a2) genes and, conversely, in down-regulation of the matrix metalloproteinase 1 (Mmp1) gene, suggesting that Fli1 suppression is involved in activ ...[more]