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The Role of IL-6 in Skin Fibrosis and Cutaneous Wound Healing.

ABSTRACT: The timely resolution of wound healing is critical for restoring the skin as a protective barrier. The switch from a proinflammatory to a reparative microenvironment must be tightly regulated. Interleukin (IL)-6 is a key modulator of the inflammatory and reparative process: it is involved in the differentiation, activation, and proliferation of leukocytes, endothelial cells, keratinocytes, and fibroblasts. This review examines the role of IL-6 in the healing of cutaneous wounds, and how dysregulation of IL-6 signaling can lead to either fibrosis or a failure to heal. The role of an IL-6/TGF-? feedback loop is discussed in the context of fibrogenesis, while IL-6 expression and responses in advanced age, diabetes, and obesity is outlined regarding the development of chronic wounds. Current research on therapies that modulate IL-6 is explored. Here, we consider IL-6's diverse impact on cutaneous wound healing.

SUBMITTER: Johnson BZ

PROVIDER: S-EPMC7277690 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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The Role of IL-6 in Skin Fibrosis and Cutaneous Wound Healing.

Johnson Blair Z BZ Stevenson Andrew W AW Prêle Cecilia M CM Fear Mark W MW Wood Fiona M FM

Biomedicines 20200430 5

The timely resolution of wound healing is critical for restoring the skin as a protective barrier. The switch from a proinflammatory to a reparative microenvironment must be tightly regulated. Interleukin (IL)-6 is a key modulator of the inflammatory and reparative process: it is involved in the differentiation, activation, and proliferation of leukocytes, endothelial cells, keratinocytes, and fibroblasts. This review examines the role of IL-6 in the healing of cutaneous wounds, and how dysregul ...[more]

PMID: 32365896

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