Ontology highlight
ABSTRACT:
SUBMITTER: Zhao M
PROVIDER: S-EPMC4316705 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Zhao Mingrui M McGarry Laura M LM Ma Hongtao H Harris Samuel S Berwick Jason J Yuste Rafael R Schwartz Theodore H TH
Frontiers in neuroscience 20150204
Animal models of epilepsy are critical not only for understanding the fundamental mechanism of epilepsy but also for testing the efficacy of new antiepileptic drugs and novel therapeutic interventions. Photorelease of caged molecules is widely used in biological research to control pharmacologic events with high spatio-temporal resolution. We developed a technique for in vivo optical triggering of neocortical seizures using a novel caged compound based on ruthenium photochemistry (RuBi-4AP). Epi ...[more]