Ontology highlight
ABSTRACT:
SUBMITTER: Hines KE
PROVIDER: S-EPMC4317543 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Hines Keegan E KE Bankston John R JR Aldrich Richard W RW
Biophysical journal 20150201 3
The ability to measure the properties of proteins at the single-molecule level offers an unparalleled glimpse into biological systems at the molecular scale. The interpretation of single-molecule time series has often been rooted in statistical mechanics and the theory of Markov processes. While existing analysis methods have been useful, they are not without significant limitations including problems of model selection and parameter nonidentifiability. To address these challenges, we introduce ...[more]