Ontology highlight
ABSTRACT:
SUBMITTER: Takahashi M
PROVIDER: S-EPMC4317889 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Takahashi Maiko M Hayashida Tetsu T Okazaki Hiroshi H Miyao Kazuhiro K Jinno Hiromitsu H Kitagawa Yuko Y
Cancer science 20140502 6
B-cell translocation gene 2 (BTG2), a gene suppressed in a subset of aggressive breast cancer, is repressed by estrogen. BTG2 inhibits the expression of HER ligands and promotes AKT activation, which plays an essential role in the tamoxifen resistance of estrogen receptor (ER)-positive breast cancer. To determine if BTG2 expression modifies tamoxifen efficacy, a cohort of 60 patients treated with adjuvant tamoxifen monotherapy was analyzed. We found that increased BTG2 expression showed better c ...[more]