Ontology highlight
ABSTRACT:
SUBMITTER: Mills JN
PROVIDER: S-EPMC6454890 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Mills Jamie N JN Rutkovsky Alex C AC Giordano Antonio A
Current opinion in pharmacology 20180430
Several mechanisms of resistance have been identified, underscoring the complex nature of estrogen receptor (ER) signaling and the many connections between this pathway and other essential signaling pathways in breast cancer cells. Many therapeutic targets of cell signaling and cell cycle pathways have met success with endocrine therapy and remain an ongoing area of investigation. This review focuses on two major pathways that have recently emerged as important opportunities for therapeutic inte ...[more]