Ontology highlight
ABSTRACT:
SUBMITTER: Lopez V
PROVIDER: S-EPMC4318148 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Lopez Virginia V Barinova Natalja N Onishi Masayuki M Pobiega Sabrina S Pringle John R JR Dubrana Karine K Marcand Stéphane S
Genes & development 20150201 3
Dicentric chromosomes are unstable products of erroneous DNA repair events that can lead to further genome rearrangements and extended gene copy number variations. During mitosis, they form anaphase bridges, resulting in chromosome breakage by an unknown mechanism. In budding yeast, dicentrics generated by telomere fusion break at the fusion, a process that restores the parental karyotype and protects cells from rare accidental telomere fusion. Here, we observed that dicentrics lacking telomere ...[more]