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Ten years and counting: moving leucine-rich repeat kinase 2 inhibitors to the clinic.

ABSTRACT: The burden that Parkinson's disease (PD) exacts on the population continues to increase year after year. Though refinement of symptomatic treatments continues at a reasonable pace, no accepted therapies are available to slow or prevent disease progression. The leucine-rich repeat kinase 2 (LRRK2) gene was identified in PD genetic studies and offers new hope for novel therapeutic approaches. The evidence linking LRRK2 kinase activity to PD susceptibility is presented, as well as seminal discoveries relevant to the prosecution of LRRK2 kinase inhibition. Finally, suggestions are made for predictive preclinical modeling and successful first-in-human trials.

SUBMITTER: West AB

PROVIDER: S-EPMC4318704 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease.

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Substrate phosphorylation of protein microarray by leucine-rich repeat kinase 2

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