Ontology highlight
ABSTRACT:
SUBMITTER: West AB
PROVIDER: S-EPMC4318704 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Movement disorders : official journal of the Movement Disorder Society 20141201 2
The burden that Parkinson's disease (PD) exacts on the population continues to increase year after year. Though refinement of symptomatic treatments continues at a reasonable pace, no accepted therapies are available to slow or prevent disease progression. The leucine-rich repeat kinase 2 (LRRK2) gene was identified in PD genetic studies and offers new hope for novel therapeutic approaches. The evidence linking LRRK2 kinase activity to PD susceptibility is presented, as well as seminal discoveri ...[more]