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The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease.

ABSTRACT: Parkinson's disease, like many common age-related conditions, is now recognized to have a substantial genetic component. Here, I discuss how mutations in a large complex gene--leucine-rich repeat kinase 2 (LRRK2)--affect protein function, and I review recent evidence that LRRK2 mutations affect pathways that involve other proteins that have been implicated in Parkinson's disease, specifically ?-synuclein and tau. These concepts can be used to understand disease processes and to develop therapeutic opportunities for the treatment of Parkinson's disease.

SUBMITTER: Cookson MR

PROVIDER: S-EPMC4662256 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature

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The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease.

Cookson Mark R MR

Nature reviews. Neuroscience 20101119 12

Parkinson's disease, like many common age-related conditions, is now recognized to have a substantial genetic component. Here, I discuss how mutations in a large complex gene--leucine-rich repeat kinase 2 (LRRK2)--affect protein function, and I review recent evidence that LRRK2 mutations affect pathways that involve other proteins that have been implicated in Parkinson's disease, specifically α-synuclein and tau. These concepts can be used to understand disease processes and to develop therapeut ...[more]

PMID: 21088684

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