Ontology highlight
ABSTRACT:
SUBMITTER: Konitsiotis AD
PROVIDER: S-EPMC4319003 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Konitsiotis Antonio D AD Jovanović Biljana B Ciepla Paulina P Spitaler Martin M Lanyon-Hogg Thomas T Tate Edward W EW Magee Anthony I AI
The Journal of biological chemistry 20141212 6
Hedgehog proteins are secreted morphogens that play critical roles in development and disease. During maturation of the proteins through the secretory pathway, they are modified by the addition of N-terminal palmitic acid and C-terminal cholesterol moieties, both of which are critical for their correct function and localization. Hedgehog acyltransferase (HHAT) is the enzyme in the endoplasmic reticulum that palmitoylates Hedgehog proteins, is a member of a small subfamily of membrane-bound O-acy ...[more]