Ontology highlight
ABSTRACT:
SUBMITTER: Luo Y
PROVIDER: S-EPMC8453165 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Luo Yitian Y Wan Guoyue G Zhou Xuan X Wang Qiuwen Q Zhang Yunbin Y Bao Juan J Cong Yao Y Zhao Yun Y Li Dianfan D
Frontiers in molecular biosciences 20210907
The evolutionarily conserved Hedgehog (Hh) signaling pathway is crucial for programmed cell differentiation and proliferation. Dispatched (Disp) is a 12-transmembrane protein that plays a critical role in the Hedgehog (Hh) signaling pathway by releasing the dually lipidated ligand HhN from the membrane, a prerequisite step to the downstream signaling cascade. In this study, we focus on the Disp from water bear, a primitive animal known as the most indestructible on Earth. Using a zebrafish model ...[more]