Ontology highlight
ABSTRACT:
SUBMITTER: Aoki Y
PROVIDER: S-EPMC4319237 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Aoki Yuki Y Watanabe Takashi T Saito Yoriko Y Kuroki Yoko Y Hijikata Atsushi A Takagi Masatoshi M Tomizawa Daisuke D Eguchi Mariko M Eguchi-Ishimae Minenori M Kaneko Akiko A Ono Rintaro R Sato Kaori K Suzuki Nahoko N Fujiki Saera S Koh Katsuyoshi K Ishii Eiichi E Shultz Leonard D LD Ohara Osamu O Mizutani Shuki S Ishikawa Fumihiko F
Blood 20141223 6
Translocation of the mixed-lineage leukemia (MLL) gene with AF4, AF9, or ENL results in acute leukemia with both lymphoid and myeloid involvement. We characterized leukemia-initiating cells (LICs) in primary infant MLL-rearranged leukemia using a xenotransplantation model. In MLL-AF4 patients, CD34(+)CD38(+)CD19(+) and CD34(-)CD19(+) cells initiated leukemia, and in MLL-AF9 patients, CD34(-)CD19(+) cells were LICs. In MLL-ENL patients, either CD34(+) or CD34(-) cells were LICs, depending on the ...[more]