Ontology highlight
ABSTRACT:
SUBMITTER: Cruickshank MN
PROVIDER: S-EPMC5220136 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Cruickshank M N MN Ford J J Cheung L C LC Heng J J Singh S S Wells J J Failes T W TW Arndt G M GM Smithers N N Prinjha R K RK Anderson D D Carter K W KW Gout A M AM Lassmann T T O'Reilly J J Cole C H CH Kotecha R S RS Kees U R UR
Leukemia 20160613 1
To address the poor prognosis of mixed lineage leukemia (MLL)-rearranged infant acute lymphoblastic leukemia (iALL), we generated a panel of cell lines from primary patient samples and investigated cytotoxic responses to contemporary and novel Food and Drug Administration-approved chemotherapeutics. To characterize representation of primary disease within cell lines, molecular features were compared using RNA-sequencing and cytogenetics. High-throughput screening revealed variable efficacy of cu ...[more]