Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen HQ
PROVIDER: S-EPMC4319363 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Nguyen Huy Q HQ Davis Ryan A RA Gervay-Hague Jacquelyn J
Angewandte Chemie (International ed. in English) 20140904 49
Steryl glycosides produced by bacteria play important biological roles in the evasion and modulation of host immunity. Step-economical syntheses of three cholesteryl-6-O-phosphatidyl-α-D-glucopyranosides (αCPG) unique to Helicobacter pylori have been achieved. The approach relies upon regioselective deprotection of per-O-trimethylsilyl-α-D-cholesterylglucoside at C6 followed by phosphoramidite coupling. Global TMS ether deprotection in the presence of oxygen and subsequent deprotection of the cy ...[more]