Ontology highlight
ABSTRACT:
SUBMITTER: Ryall JG
PROVIDER: S-EPMC4320668 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Cell stem cell 20150115 2
Stem cells undergo a shift in metabolic substrate utilization during specification and/or differentiation, a process that has been termed metabolic reprogramming. Here, we report that during the transition from quiescence to proliferation, skeletal muscle stem cells experience a metabolic switch from fatty acid oxidation to glycolysis. This reprogramming of cellular metabolism decreases intracellular NAD(+) levels and the activity of the histone deacetylase SIRT1, leading to elevated H4K16 acety ...[more]