Ontology highlight
ABSTRACT:
SUBMITTER: Jyothi KR
PROVIDER: S-EPMC4321639 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Jyothi K R KR Beloor Jagadish J Jo Ara A Nguyen Minh Nam MN Choi Tae Gyu TG Kim Jin-Hwan JH Akter Salima S Lee Sang-Kyung SK Maeng Chi Hoon CH Baik Hyung Hwan HH Kang Insug I Ha Joohun J Kim Sung Soo SS
International journal of nanomedicine 20150130
Therapeutic options for hepatitis C virus (HCV) infection have been limited by drug resistance and adverse side effects. Targeting the host factor cyclophilin A (CypA), which is essential for HCV replication, offers a promising strategy for antiviral therapy. However, due to its immunosuppressive activity and severe side effects, clinical application of cyclosporine A (CsA) has been limited as an antiviral agent. To overcome these drawbacks, we have successfully developed a liver-specific, susta ...[more]