Ontology highlight
ABSTRACT:
SUBMITTER: Li L
PROVIDER: S-EPMC4322039 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Li Lei L Zheng Hong-Xiang HX Liu Zuyun Z Qin Zhendong Z Chen Fei F Qian Degui D Xu Jun J Jin Li L Wang Xiaofeng X
Age (Dordrecht, Netherlands) 20150210 1
Genetic variants of whole mitochondrial DNA (mtDNA) that predispose to exceptional longevity need to be systematically identified and appraised. Here, we conducted a case-control study with 237 exceptional longevity subjects (aged 95-107) and 444 control subjects (aged 40-69) randomly recruited from a "longevity town"-the city of Rugao in China-to investigate the effects of mtDNA variants on exceptional longevity. We sequenced the entire mtDNA genomes of the 681 subjects using a next-generation ...[more]