Ontology highlight
ABSTRACT:
SUBMITTER: Weber JP
PROVIDER: S-EPMC4322049 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20150202 2
The co-stimulators ICOS (inducible T cell co-stimulator) and CD28 are both important for T follicular helper (TFH) cells, yet their individual contributions are unclear. Here, we show that each molecule plays an exclusive role at different stages of TFH cell development. While CD28 regulated early expression of the master transcription factor Bcl-6, ICOS co-stimulation was essential to maintain the phenotype by regulating the novel TFH transcription factor Klf2 via Foxo1. Klf2 directly binds to ...[more]