Ontology highlight
ABSTRACT:
SUBMITTER: Gong B
PROVIDER: S-EPMC4322565 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Gong Binsheng B Wang Charles C Su Zhenqiang Z Hong Huixiao H Thierry-Mieg Jean J Thierry-Mieg Danielle D Shi Leming L Auerbach Scott S SS Tong Weida W Xu Joshua J
Scientific data 20140826
RNA-Seq provides the capability to characterize the entire transcriptome in multiple levels including gene expression, allele specific expression, alternative splicing, fusion gene detection, and etc. The US FDA-led SEQC (i.e., MAQC-III) project conducted a comprehensive study focused on the transcriptome profiling of rat liver samples treated with 27 chemicals to evaluate the utility of RNA-Seq in safety assessment and toxicity mechanism elucidation. The chemicals represented multiple chemogeno ...[more]