Time-resolved gene expression profiling during reprogramming of C/EBP?-pulsed B cells into iPS cells.
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ABSTRACT:
SUBMITTER: Di Stefano B
PROVIDER: S-EPMC4322579 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Time-resolved gene expression profiling during reprogramming of C/EBPα-pulsed B cells into iPS cells.
Di Stefano Bruno B Collombet Samuel S Graf Thomas T
Scientific data 20140527
The reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) is lengthy and inefficient. The development of a reprogramming system that allows rapid and synchronous reprogramming to pluripotency is imperative for understanding the mechanism of iPSC formation and for future therapeutic applications. We have recently reported that a short expression in mouse primary B cells of the transcription factor C/EBPα before the induction of pluripotency factors increases the iPSC reprogramm ...[more]
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