Ontology highlight
ABSTRACT:
SUBMITTER: Molnar KS
PROVIDER: S-EPMC4322757 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Molnar Kathleen S KS Bonomi Massimiliano M Pellarin Riccardo R Clinthorne Graham D GD Gonzalez Gabriel G Goldberg Shalom D SD Goulian Mark M Sali Andrej A DeGrado William F WF
Structure (London, England : 1993) 20140731 9
Bacteria transduce signals across the membrane using two-component systems (TCSs), consisting of a membrane-spanning sensor histidine kinase and a cytoplasmic response regulator. In gram-negative bacteria, the PhoPQ TCS senses cations and antimicrobial peptides, yet little is known about the structural changes involved in transmembrane signaling. We construct a model of PhoQ signal transduction using Bayesian inference, based on disulfide crosslinking data and homologous crystal structures. The ...[more]