Ontology highlight
ABSTRACT:
SUBMITTER: Chung AY
PROVIDER: S-EPMC4322772 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Cancer research 20140916 19
Immune dysregulation drives the pathogenesis of chronic inflammatory, autoimmune, and dysplastic disorders. While often intended to address localized pathology, most immune modulatory therapies are administered systemically and carry inherent risk of multiorgan toxicities. Here, we demonstrate, in a murine model of spontaneous gastrointestinal polyposis, that site-specific uptake of orally administered IL10 microparticles ameliorates local and systemic disease to enhance survival. Mechanistic in ...[more]